Some of these cells will differentiate into capillaries, while others will become osteogenic cells and then osteoblasts. ![]() The process begins when mesenchymal cells in the embryonic skeleton gather together and begin to differentiate into specialized cells ( Figure 6.4.1 a). The flat bones of the face, most of the cranial bones, and the clavicles (collarbones) are formed via intramembranous ossification. Intramembranous Ossificationĭuring intramembranous ossification, compact and spongy bone develops directly from sheets of mesenchymal (undifferentiated) connective tissue. There are two osteogenic pathways-intramembranous ossification and endochondral ossification-but in the end, mature bone is the same regardless of the pathway that produces it. By the sixth or seventh week of embryonic life, the actual process of bone development, ossification (osteogenesis), begins. In the early stages of embryonic development, the embryo’s skeleton consists of fibrous membranes and hyaline cartilage.
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